Solution Based Modelling - définition. Qu'est-ce que Solution Based Modelling
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Qu'est-ce (qui) est Solution Based Modelling - définition

PBPK; Pbpk modelling; Physiologically-based pharmacokinetic modelling; Physiologically-based toxicokinetic modelling; Physiologically-based biokinetic modelling; Physiologically-based pharmacokinetic modeling
  • elimination half-life]] of 4 hours, and an apparent [[volume of distribution]] of 10 liters.
  • url=https://dx.doi.org/10.1371%2Fjournal.pone.0123461%7Cauthor(s)=Andrew D. Wong, Mao Ye, Martin B. Ulmschneider, Peter C. Searson}}</ref>

Solution Based Modelling      
(SBM) A software development process described in the book "Developing Object-Oriented Software for the Macintosh" written by Neal Goldstein and Jeff Alger, published by Addison Wesley in 1992.
Ringer's solution         
  • Ringer's solution
ELECTROLYTE SOLUTION FOR USE IN HEALTHCARE
Ringer's Solution; Ringer solution; Ringers solution; Ringer's fluid
Ringer's solution is a solution of several salts dissolved in water for the purpose of creating an isotonic solution relative to the body fluids of an animal. Ringer's solution typically contains sodium chloride, potassium chloride, calcium chloride and sodium bicarbonate, with the last used to balance the pH.
Geologic modelling         
  •  Geological mapping software displaying a screenshot of a structure map generated for an 8500ft deep gas & [[Oil reservoir]] in the Earth field, [[Vermilion Parish]], [[Erath, Louisiana]]. The left-to-right gap, near the top of the [[contour map]] indicates a [[Fault line]].  This fault line is between the blue/green contour lines and the purple/red/yellow contour lines.  The thin red circular contour line in the middle of the map indicates the top of the oil reservoir. Because gas floats above oil, the thin red contour line marks the gas/oil contact zone.
  • Gravity Highs
APPLIED SCIENCE OF CREATING COMPUTERIZED REPRESENTATIONS OF PORTIONS OF THE EARTH'S CRUST
Geologic modeling; Geological modelling; Geomodeling; Geomodelling; Geological model
Geologic modelling, geological modelling or geomodelling is the applied science of creating computerized representations of portions of the Earth's crust based on geophysical and geological observations made on and below the Earth surface. A geomodel is the numerical equivalent of a three-dimensional geological map complemented by a description of physical quantities in the domain of interest.

Wikipédia

Physiologically based pharmacokinetic modelling

Physiologically based pharmacokinetic (PBPK) modeling is a mathematical modeling technique for predicting the absorption, distribution, metabolism and excretion (ADME) of synthetic or natural chemical substances in humans and other animal species. PBPK modeling is used in pharmaceutical research and drug development, and in health risk assessment for cosmetics or general chemicals.

PBPK models strive to be mechanistic by mathematically transcribing anatomical, physiological, physical, and chemical descriptions of the phenomena involved in the complex ADME processes. A large degree of residual simplification and empiricism is still present in those models, but they have an extended domain of applicability compared to that of classical, empirical function based, pharmacokinetic models. PBPK models may have purely predictive uses, but other uses, such as statistical inference, have been made possible by the development of Bayesian statistical tools able to deal with complex models. That is true for both toxicity risk assessment and therapeutic drug development.

PBPK models try to rely a priori on the anatomical and physiological structure of the body, and to a certain extent, on biochemistry. They are usually multi-compartment models, with compartments corresponding to predefined organs or tissues, with interconnections corresponding to blood or lymph flows (more rarely to diffusions). A system of differential equations for concentration or quantity of substance on each compartment can be written, and its parameters represent blood flows, pulmonary ventilation rate, organ volumes etc., for which information is available in scientific publications. Indeed, the description they make of the body is simplified and a balance needs to be struck between complexity and simplicity. Besides the advantage of allowing the recruitment of a priori information about parameter values, these models also facilitate inter-species transpositions or extrapolation from one mode of administration to another (e.g., inhalation to oral). An example of a 7-compartment PBPK model, suitable to describe the fate of many solvents in the mammalian body, is given in the Figure on the right.